Martin PJ van Boxtel, MD PhD

Van Asbroeck, S., van Boxtel, M. P. J., Steyaert, J., Kohler, S., Heger, I., de Vugt, M., . . . Deckers, K. (2021). Increasing knowledge on dementia risk reduction in the general population: Results of a public awareness campaign. Prev Med, 147, 106522. doi:10.1016/j.ypmed.2021.106522

 

Vergoossen, L. W. M., Jansen, J. F. A., van Sloten, T. T., Stehouwer, C. D. A., Schaper, N. C., Wesselius, A., . . . Backes, W. H. (2021). Interplay of White Matter Hyperintensities, Cerebral Networks, and Cognitive Function in an Adult Population: Diffusion-Tensor Imaging in the Maastricht Study. Radiology, 298(2), 384-392. doi:10.1148/radiol.2021202634

 

Verheggen, I. C. M., de Jong, J. J. A., van Boxtel, M. P. J., Postma, A. A., Verhey, F. R. J., Jansen, J. F. A., & Backes, W. H. (2020). Permeability of the windows of the brain: Feasibility of dynamic contrast-enhanced MRI of the circumventricular organs. Fluids and Barriers of the CNS, 17(1), 66.

 

Verheggen, I. C. M., de Jong, J. J. A., van Boxtel, M. P. J., Postma, A. A., Jansen, J. F. A., Verhey, F. R. J., & Backes, W. H. (2020). Imaging the role of blood-brain barrier disruption in normal cognitive ageing. Geroscience, 42(6), 1751-1764. doi:10.1007/s11357-020-00282-1

 

Van Beers, M., Gosker, H. R., Janssen, D. J. A., Cleutjens, F., Franssen, F. M. E., van Boxtel, M. P. J., . . . Schols, A. (2020). Cognitive performance in relation to metabolic disturbances in patients with COPD. Clin Nutr, S0261-5614. doi:10.1016/j.clnu.2020.09.029

 

Bae, J. B., Lipnicki, D. M., Han, J. W., Sachdev, P. S., Kim, T. H., Kwak, K. P., . . . for Cohort Studies of Memory in an International, C. (2020). Does parity matter in women's risk of dementia? A COSMIC collaboration cohort study. BMC Med, 18(1), 210.

 

Verheggen, I. C. M., de Jong, J. J. A., van Boxtel, M. P. J., Gronenschild, E. H., Palm, W. M., Postma, A. A., . . . Backes, W. H. (2020). Increase in blood-brain barrier leakage in healthy, older adults. Geroscience, 42(4): 1183-1193.

 

Rensma, S., van Sloten, T., Houben, B., van Boxtel, M., Berendschot, T., Jansen, J. F. A., . . . Stehouwer, C. (2020). Associations of arterial stiffness with cognitive performance, and the role of microvascular dysfunction: The Maastricht Study. Hypertension, 75(6), 1607-1614.

 

Vergoossen, L. W., Schram, M. T., de Jong, J. J., Stehouwer, C. D., Schaper, N. C., Henry, R. M., . . . Jansen, J. F. (2020). White Matter Connectivity Abnormalities in Prediabetes and Type 2 Diabetes: The Maastricht Study. Diabetes Care, 43(1), 201-208.

 

Peters, R., Yasar, S., Anderson, C., Andrews, S., Antikainen, R., Arima, H., . . . Anstey, K. J. (2020). An investigation of antihypertensive class, dementia and cognitive decline. A meta-analysis. Neurology, 94(3), e267-e281.

 

Deckers, K., Barbera, M., Kohler, S., Ngandu, T., van Boxtel, M., Rusanen, M., . . . Solomon, A. (2020). Long-term dementia risk prediction by the LIBRA score: a 30-year follow-up of the CAIDE study. Int J Geriatr Psychiatry, 35(2), 195-203.

 

Van Boxtel, M. P. J., Berk, L., de Vugt, M., & Warmenhoven, F. (2020). Mindfulness-based interventions for people with dementia and their caregivers: Keeping a dyadic balance [Editorial]. Aging and Mental Health, 24(5), 697-699.

 

Lipnicki, D. M., Makkar, S. R., Crawford, J. D., Thalamuthu, A., Kochan, N. A., Lima-Costa, M. F., . . . Sachdev, P. S. (2019). Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study. PLoS Med, 16(7), e1002853.

 

Deckers, K., Cadar, D., van Boxtel, M. P. J., Verhey, F. R. J., Steptoe, A., & Kohler, S. (2019). Modifiable Risk Factors Explain Socioeconomic Inequalities in Dementia Risk: Evidence from a Population-Based Prospective Cohort Study. Journal of Alzheimer's disease, 71(2), 549-557.

 

Rensma, S. P., van Sloten, T. T., Houben, A., Kohler, S., van Boxtel, M. P. J., Berendschot, T., . . . Stehouwer, C. D. A. (2020). Microvascular Dysfunction Is Associated With Worse Cognitive Performance: The Maastricht Study. Hypertension, 75(1), 237-245.

 

Berk, L., Warmenhoven, F., van Os, J., & van Boxtel, M. (2019). Mindfulnesstraining voor mensen met dementie en hun mantelzorgers: Rationale, status huidig onderzoek en toekomstige mogelijkheden. Tijdschrift voor Neuropsychologie, 14(2), 115-125.

 

Heger, I., Deckers, K., van Boxtel, M., de Vugt, M., Hajema, K. J., Verhey, F., & Koehler, S. (2019). Dementia awareness and risk perception in middle-aged and older individuals: baseline results of the MijnBreincoach survey on the association between lifestyle and brain health. BMC Public Health, 19(1):678.

 

Qi, Y., Koster, A., van Boxtel, M. P. J., Köhler, S., Schram, M., Schaper, N., et al. (2019). Adulthood Socioeconomic Position and Type 2 Diabetes Mellitus-A Comparison of Education, Occupation, Income, and Material Deprivation: The Maastricht Study. International Journal of Environmental Research and Public Health, 16(8): 1435.

 

Berk, L., Warmenhoven, F., Stiekema, A. P. M., van Oorsouw, K., van Os, J., de Vugt, M., & van Boxtel, M. (2019). Mindfulness-based Intervention for People with Dementia and their Partners: Results of a Mixed-Methods Study. Frontiers in Aging Neuroscience, 11, 92.

 

McGarrigle, L., Irving, K., van Boxtel, M. P. J., & Boran, L. (2019). Cognitive Reserve Capacity: Exploring and Validating a Theoretical Model in Healthy Ageing. J Int Neuropsychol Soc, 25(6), 603-617. doi:10.1017/S1355617719000250

 

Zhou, T. L., Henry, R. M. A., Kroon, A. A., Stehouwer, C. D. A., van Boxtel, M. P. J., Verhey, F., . . . van Sloten, T. T. (2019). Greater Blood Pressure Variability Is Associated With Lower Cognitive Performance – The Maastricht Study. Hypertension, 73(4), 803-811.

 

Dam, A. E. H., Christie, H. L., Smeets, C. M. J., van Boxtel, M. P. J., Verhey, F. R. J., & de Vugt, M. E. (2019). Process evaluation of a social support platform 'Inlife' for caregivers of people with dementia. Internet Interv, 15, 18-27. doi:10.1016/j.invent.2018.09.002

 

Veugen, M. G. J., Henry, R. M. A., Brunner-La Rocca, H. P., Dagnelie, P. C., Schram, M. T., van Agtmaal, M. J. M., . . . Stehouwer, C. D. A. (2018). Cross-sectional associations between cardiac biomarkers, cognitive performance, and structural brain changes are modified by age. Arterioscler Thromb Vasc Biol, 38(8), 1948-1958. doi:10.1161/ATVBAHA.118.311082

 

Deckers, K., Nooyens, A., van Boxtel, M., Verhey, F., Verschuren, M., & Kohler, S. (2019). Gender and Educational Differences in the Association between Lifestyle and Cognitive Decline over 10 Years: The Doetinchem Cohort Study. J Alzheimers Dis, 70(s1), S31-S41. doi:10.3233/JAD-180492

 

Deckers, K., & van Boxtel, M. (2019). Vascular disease-based risk factors for dementia. In K. Irving, E. Hogervorst, D. Oliveira, & M. Kivipelto (Eds.), New developments in dementia prevention research: state of the art and future possibilities. New York: Routledge.

 

Gulpers, B., Oude Voshaar, R. C., van Boxtel, M. P. J., Verhey, F. R. J., & Köhler, S. (2018 [Epub ahead of print]). Anxiety as a risk factor for cognitive decline: A twelve year follow-up cohort study. American Journal of Geriatric Psychiatry, 27(1), 42-52.

 

Van Boxtel, M. (2018). Aanwezig zijn in het moment: Aandachtstraining voor mensen met dementie en hun mantelzorger. Denkbeeld, 5(oktober), 32-34.

 

Uthaug, M. V., van Oorsouw, K., Kuypers, K. P. C., van Boxtel, M. P. J., Broers, N. J., Mason, N. L., . . . Ramaekers, J. G. (2018). Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution. Psychopharmacology, 235(10), 2979-2989. doi:10.1007/s00213-018-4988-3

 

Geijselaers, S. L., Sep, S. J., Schram, M. T., van Boxtel, M. P., van Sloten, T. T., Op Het Roodt, J., . . . Stehouwer, C. D. (2018). Carotid circumferential wall stress is not associated with cognitive performance among individuals in late middle age: The Maastricht Study. Atherosclerosis, 276, 15-22. doi:10.1016/j.atherosclerosis.2018.07.003

 

Berk, L., Warmenhoven, F., van Os, J., & van Boxtel, M. (2018). Mindfulness Training for People with Dementia and their Caregivers: Rationale, Current Research, and Future Directions. 9, 982. Frontiers in Psychology.

 

Veugen, M. G. J., Henry, R. M. A., Brunner-La Rocca, H.-P., Dagnelie, P. C., Schram, M. T., van der Kallen, C. J. H., Sep, S. J. S., van Boxtel, M. P. J., . . . Stehouwer, C. D. A. (2018 [Epub ahead of print]). Biomarkers of left ventricular dysfunction and ischaemia are independently associated with abnormalities on brain MRI in both older and younger individuals, but with cognitive performance only in older individuals: The Maastricht Study. Arteriosclerosis, Thrombosis, and Vascular Biology.

 

Verheggen, I. C. M., Van Boxtel, M. P. J., Verhey, F. R. J., Jansen, J. F. A., & Backes, W. H. (2018). Interaction between blood-brain barrier and glymphatic system in solute clearance. Neurosci Biobehav Rev, 90, 26-33. doi:10.1016/j.neubiorev.2018.03.028

 

Van Oostrom, S. H., Nooyens, A. C. J., van Boxtel, M. P. J., & Verschuren, W. M. M. (2018). Long sleep duration is associated with lower cognitive function among middle-age adults: the Doetinchem Cohort Study. Sleep Medicine, 41, 78-85.

 

Schiepers, O. J., Köhler, S., Deckers, K., Irving, K., O'Donnell, C. A., van den Akker, M., . . . van Boxtel, M. P. J. (2018). LIfestyle for BRAin Health (LIBRA): a new model for dementia prevention. International Journal of Geriatric Psychiatry, 33(1), 167-175.

 

Nooyens, A. C. J., van Gelder, B. M., Bueno-de-Mesquita, H. B., van Boxtel, M. P. J., & Verschuren, W. M. (2018). Fish consumption, intake of fats and cognitive decline at middle-age – the Doetinchem Cohort Study. European Journal of Nutrition, 57(4):1667-1675.

 

Berk, L., Hotterbeekx, R., van Os, J., & van Boxtel, M. (2017 [Epub ahead of print]). Mindfulness-Based Stress Reduction in Middle-Aged and Older Adults with Memory Complaints: A Mixed-Methods Study. Aging and Mental Health.

 

Schievink, S., van Boxtel, M., Deckers, K., van Oostenbrugge, R., Verhey, F., & Köhler, S. (2017 [Epub ahead of print]). Cognitive changes in individuals with prevalent and incident cardiovascular disease: a 12-year follow-up in the Maastricht Aging Study (MAAS). European Heart Journal.

 

Deckers, K., Schievink, S., Rodriquez, M., van Oostenbrugge, R., van Boxtel, M., Verhey, F., & Köhler, S. (2017). Coronary heart disease and risk for cognitive impairment or dementia: Systematic review and meta-Analysis. PLOS One, 12(9):e0184244

 

Dam, A., de Vugt, M., van Boxtel, M., & Verhey, F. (2017). Effectiveness of an Online Social Support Intervention for caregivers of people with dementia: study protocol of a randomized controlled trial. Trials, 18(1), 395.

 

Dam, A. E. H., van Boxtel, M. P. J., Rozendaal, N., Verhey, F. R., & de Vugt, M. E. (2017 [Epub ahead of print]). Development and feasibility of Inlife: a pilot study of an online social support intervention for informal caregivers of people with dementia. PLOS One.

 

Dam, A. E., Boots, L. M. M., van Boxtel, M. P., Verhey, F. R., & de Vugt, M. E. (2017). A mismatch between supply and demand of social support in dementia care: a qualitative study on the perspectives of spousal caregivers and their social network members. International Psychogeriatrics, 18(1), 395.

 

Geijselaers, S. L., Sep, S. J., Claessens, D., Schram, M. T., van Boxtel, M. P., Henry, R. M., . . . Stehouwer, C. D. (2017). The Role of Hyperglycemia, Insulin Resistance, and Blood Pressure in Diabetes-Associated Differences in Cognitive Performance-The Maastricht Study. Diabetes Care, 40(11), 1537-1547.

 

Spauwen, P. J., Murphy, R. A., Jonsson, P. V., Sigurdsson, S., Garcia, M. E., Eiriksdottir, G., . . . Launer, L. J. (2017). Associations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study. Age and Ageing, 46(2), 250-257.

 

Deckers, K., Kohler, S., van Boxtel, M., Verhey, F., Brayne, C., Fleming, J., & collaboration, C. C. s. (2017 [Epub ahead of print]). Lack of associations between modifiable risk factors and dementia in the very old: findings from the Cambridge City over-75s cohort study. Aging Ment Health.

 

Geijselaers, S. L., Sep, S. J., Schram, M. T., van Boxtel, M. P., Henry, R. M., Verhey, F. R., . . . Biessels, G. J. (2017). Insulin resistance and cognitive performance in type 2 diabetes - The Maastricht study. J Diabetes Complications, 31(5), 824-830.

 

Vos, S. J. B., van Boxtel, M. P. J., Schiepers, O. J. G., Deckers, K., de Vugt, M., Carrière, I., . . . Koehler, S. (2017). Modifiable Risk Factors for Prevention of Dementia in Midlife, Late Life and the Oldest-Old: Validation of the LIBRA Index Journal of Alzheimer's Disease, 58(2), 537-547.

 

Deckers, K., Camerino, I., van Boxtel, M. P., Verhey, F. R., Irving, K., Brayne, C., . . . Kohler, S. (2017). Dementia risk in renal dysfunction: A systematic review and meta-analysis of prospective studies. Neurology, 88(2):198-208. [See also author response in Neurology.,2017, 89(21):2214-2215,

 

Deckers, K., Camerino, I., van Boxtel, M. P. J., Verhey, F. R. J., Irving, K., Brayne, C., . . . Kohler, S. (2017). Author response: Dementia risk in renal dysfunction: A systematic review and meta-analysis of prospective studies. Neurology, 89(21), 2214-2215.

 

Deckers, K., van Boxtel, M. P. J., Verhey, F. R. J., & Köhler, S. (2017). Obesity and cognitive decline in adults: Effects of methodological choices and confounding by age in a longitudinal study. Journal of Nutrition Health & Aging, 21(5), 546-553.

 

Van Bussel, F. C. G., Jansen, J. F. A., van de Haar, H. J., van Osch, M. J. P., Hofman, P. A. M., van Boxtel, M. P. J., . . . Backes, W. H. (2016). Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus. Scientific Reports 6(1):10.

 

Van Bussel, F. C. G., Backes, W. H., Hofman, P. A. M., van Oostenbrugge, R. J., van Boxtel, M. P. J., Verhey, F. R., . . . Jansen, J. F. A. (2017). Cerebral pathology and cognition in diabetes: The merits of multiparametric neuroimaging. Frontiers in Neuroscience, 11, 188.

 

Berk, L., van Boxtel, M., & van Os, J. (2017). Can Mindfulness-Based Interventions Influence Cognitive Functioning in Older Adults? A Review and Considerations for Future Research. Aging and Mental Health, 21(11), 1113-1120.

 

Berk, L., van Boxtel, M. P. J., Koehler, S., & J., v. O. (2017). Positive Affect and Cognitive Decline: a 12-year follow-up of the Maastricht Aging Study. International Journal of Geriatric Psychiatry, 32(12), 1305-1311.

 

Spauwen, P. J. J., Martens, R. J. H., Stehouwer, C. D. A., Verhey, F. R. J., Schram, M. T., Sep, S. J. S., . . . van Boxtel, M. P. J. (2017). Lower verbal intelligence is associated with diabetic complications and slower walking speed in individuals with type 2 diabetes: The Maastricht Study. Diabetic Medicine, 33(12), 1632-1639.

 

Van Bussel, F. C. G., Backes, W. H., Hofman, P. A. M., Puts, N. A. J., Edden, R. A. E., van Boxtel, M. P. J., . . . Jansen, J. F. A. (2016). Increased GABA concentrations in Type 2 Diabetes Mellitus are related to lower cognitive functioning. Medicine, 95(36):e4803.

 

Dichgans, M., Wardlaw, J., Smith, E., Zietemann, V., Seshadri, S., Sachdev, P., . . . Yang, Y. H. (2016). METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimers Dementia, 12(12), 1235-1249.

 

Geijselaers, S. L. C., Sep, S. J. S., Schram, M. T., van Boxtel, M. P. J., van Sloten, T. T., Henry, R. M. A., . . . Stehouwer, C. D. A. (2016). Carotid stiffness is associated with impairment of cognitive performance in individuals with and without type 2 diabetes: The Maastricht Study. Atherosclerosis, 253:186-193.

 

Martens, R. J., Kooman, J. P., Stehouwer, C. D., Dagnelie, P. C., van der Kallen, C. J., Koster, A., . . . Henry, R. M. (2016). Estimated GFR, Albuminuria, and Cognitive Performance: The Maastricht Study. American Journal of Kidney Diseases, 69(2), 179-191.

 

Jansen, J. F., van Bussel, F. C., van de Haar, H. J., van Osch, M. J., Hofman, P. A., van Boxtel, M. P., . . . Backes, W. H. (2016). Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus. Science Reports, 6(1), 10.

 

Van Bussel, F. C. G., Backes, W. H., van Veenendaal, T. M., Hofman, P. A. M., van Boxtel, M. P. J., Schram, M. T., . . . Jansen, J. F. A. (2016). Functional brain networks are altered in type 2 diabetes and pre-diabetes: Signs for compensation of cognitive decrements? - The Maastricht Study. Diabetes, 65(8), 2404-2413.

See also erratum in Diabetes 2016;65:2404-2413.

 

Dam, A. E., de Vugt, M. E., Klinkenberg, I. P., Verhey, F. R., & van Boxtel, M. P. (2016). A systematic review of social support interventions for caregivers of people with dementia: Are they doing what they promise? Maturitas, 85, 117-130.

 

Van Bussel, F. C. G., Backes, W. H., Hofman, P. A. M., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., . . . Jansen, J. F. A. (2016). Altered hippocampal white matter connectivity in Type 2 Diabetes Mellitus and memory decrements. Journal of Neuroendocrinology, 28(3), 12366.

 

Van Tetering, M. A. J., Reijnders, J. S. A. M., Geusgens, C. A. V., Ponds, R. W. H. M., & van Boxtel, M. P. J. (2016). “Houd uw brein vitaal!” een online psycho-educatief programma voor gezonde cognitieve veroudering. Tijdschrift voor Neuropsychologie, 11(3), 213-228.

 

O’Donnell, C. A., Browne, S., Pierce, M., McConnachie, A., Deckers, K., van Boxtel, M. P. J., . . . Irving, K. (2015). Reducing dementia risk by targeting modifiable risk factors in mid-life: study protocol for the Innovative Midlife Intervention for Dementia Deterrence (In-MINDD) randomised controlled feasibility trial. Pilot and Feasibility Studies, 1, 40.

 

Van Os, Y., de Vugt, M., & van Boxtel, M. (2015). Cognitive interventions in older persons: Do they change the functioning of the brain? Biomed Research International, 438908.

 

Spauwen, P. J., van Boxtel, M. P., Verhey, F. R., Kohler, S., Sep, S. J., Koster, A., . . . Stehouwer, C. D. (2015). Both Low and High 24-Hour Diastolic Blood Pressure Are Associated With Worse Cognitive Performance in Type 2 Diabetes: The Maastricht Study. Diabetes Care, 38(8), 1473-1480.

 

Nooyens, A. C. J., Bueno-de-Mesquita, H. B., Baak, B., Milder, I., van Boxtel, M. P. J., & Verschuren, W. M. (2015). Diet and cognitive decline at middle age: the role of antioxidants. British Journal of Nutrition, 113(9), 1410-1417. 

 

Reijnders, J., van Heugten, C., & van Boxtel, M. (2015; Epub ahead of print). ‘Keep your brain fit!’ A psychoeducational training program for healthy cognitive aging: a feasibility study. Educational Gerontology, 41(8), 613-620.

 

Jacobs, H. I., Gronenschild, E. H., Evers, E. A., Ramakers, I. H., Hofman, P. A., Backes, W. H., . . . van Boxtel, M. P. (2015). Visuospatial processing in early Alzheimer's disease: A multimodal neuroimaging study. Cortex, 64, 394-406.

 

Van Bussel, F. C., Backes, W. H., Hofman, P. A., van Oostenbrugge, R. J., Kessels, A. G., van Boxtel, M. P., . . . Jansen, J. F. (2015). On the Interplay of Microvasculature, Parenchyma, and Memory in Type 2 Diabetes. Diabetes Care, 38(5):876-82.

 

Roantree, M., O' Donoghue, J., O' Kelly, N., Pierce, M., Irving, K., van Boxtel, M. P. J., & Kohler, S. (2015). Mapping longitudinal studies to risk factors in an ontology for dementia. Health Informatics Journal, 22(2):414-426.

 

Spauwen, P. J., van Eupen, M. G., Kohler, S., Stehouwer, C. D., Verhey, F. R., van der Kallen, C. J., . . . van Boxtel, M. P. (2015). Associations of advanced glycation endproducts with cognitive functions in individuals with and without type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 100(3):951-960.

 

Aarts, S., Patel, K. V., Garcia, M. E., van den Akker, M., Verhey, F. R. J., Metsemakers, J. F. M., . . . Launer, L. J. . (2015). Co-presence of multimorbidity and disability with frailty: an examination of heterogeneity in the frail older population. Journal of Frailty and Aging, 4(3), 131-138.

 

De Grip, A., Dupuy, A., Jolles, J., & van Boxtel, M. (2015). Retirement and Cognitive Development in the Netherlands: Are the Retired Really Inactive? Economics and Human Biology, 19, 157-169.

 

Deckers, K., van Boxtel, M. P., Schiepers, O. J., de Vugt, M., Muñoz Sánchez, J. L., Anstey, K. J., . . . Köhler, S. (2015). Target risk factors for dementia prevention: A systematic review and Delphi consensus study on the evidence from observational studies. International Journal of Geriatric Psychiatry, 30(3), 234-46.

 

Jacobs, H. I., Gronenschild, E. H., Evers, E. A., Ramakers, I. H., Hofman, P. A., Backes, W. H., et al. (2015). Visuospatial processing in early Alzheimer's disease: a multimodal neuroimaging study. Cortex, 64, 394-406

 

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